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1-Fluorocyclopropanecarboxylic acid

1-Fluorocyclopropanecarboxylic acid
CAS#: 137081-41-5
Size: 1g
$490.00

WZ4002

WZ4002
CAS#: 1213269-23-8
Size: 5mg
$145.00

(S)-4-hydroxy-4-ethyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

(S)-4-hydroxy-4-ethyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
CAS#: 110351-94-5
Size:100mg
$580.00

TLC Spotting Capillary Tubes

0.3mm ID, 100mm Length, 1000/PK
$50.00

BARREL-SHAPED Filter Funnel with Celite

18 mL, 0.5 g Celite
50/pk
$163.00

Chiral Analytical HPLC Column

0201-000001
Venusil CA
5μm, 1000 Å
4.6×150mm
each
$1,170.00

Flash Column, Silica

0303-000138
Silica
40-60μm, 60Å, 20g
20/pk
$98.00

Non-Sterile Syringe Filters

IC-Nylon Syringe Filters, 13mm, 0.22um, 200/PK
$149.00

TL8-113

Size: 5mg
$350.00

CT99021

CT99021
CAS#: 252917-06-9
Size:1g
$624.00

Big News

Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer

Abstract: We demonstrate that both b3 integrin and fibroblast growth factor receptor-1 (FGFR1) are part of an epithelial–mesenchymal transition (EMT) program that is required to facilitate metastatic outgrowth in response to fibroblast growth factor-2 (FGF2). Mechanistically, b3 integrin physically disru pts an interaction between FGFR1 and E-cadherin, leading to a dramatic redistribution of FGFR1 subcellular localization, enhanced FGF2 signaling and increased three-dimensional (3D) outgrowth of metastatic breast cancer cells. This ability of b3 integrin to drive FGFR signaling requires the enzymatic activity of focal adhesion kinase (FAK). Importantly, covalent targeting of a conserved cysteine in the P-loop of FGFR1–4 with our newly developed small molecule, FIIN-4(http://www.achemtek.com/0107-000063), more effectively blocks 3D metastatic outgrowth as compared with currently available FGFR inhibitors. In vivo application of FIIN-4 potently inhibited the growth of metastatic, patient-derived breast cancer xenografts and murine-derived metastases growing within the pulmonary microenvironment. More... 
Mol Cancer Ther; 15(9); 2096–106. 2016 AACR.

 

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A ChemTek locates in Worcser MA provides chemicals, analytical, purification products and services to world-wide pharmaceutical researchers in an Easy, Economic, Efficient & Express way. The major products include Amino Acids, Bioactive Reference Compounds, Nature Products, Building Blocks; WE also distribute HPLC/prep-HPLC/flash columns, chromatography systems,  TLC, silica gel, syringe filters, vials etc.

 

Great news! The 2015 Fall ACS National Meeting and Exposition will open in August, 2015 at Boston Convention & Exhibition Center. A Chemtek Inc. will participate in the grand exhibition. Come and meet us at booth #914 then!

 

(Picture from http://www.acs.org/content/acs/en/meetings/boston---fall-2015.html)