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A Chemtek Inc. is an ISO 9001 certified manufacturer now!

A ChemTek provides chemical products and services to pharmaceutical researchers worldwide. We pride ourselves in making the purchasing process simple and efficient, with reasonable pricing for a wide variety of products. Our chemical stock contains amino acids, bioactive reference compounds, nature products, building blocks, and more. We also supply consumable lab equipment like HPLC/prep-HPLC/flash columns, chromatography systems, TLC, silica gel, syringe filters, and vials.



Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer


Abstract: We demonstrate that both b3 integrin and fibroblast growth factor receptor-1 (FGFR1) are part of an epithelial–mesenchymal transition (EMT) program that is required to facilitate metastatic outgrowth in response to fibroblast growth factor-2 (FGF2). Mechanistically, b3 integrin physically disru pts an interaction between FGFR1 and E-cadherin, leading to a dramatic redistribution of FGFR1 subcellular localization, enhanced FGF2 signaling and increased three-dimensional (3D) outgrowth of metastatic breast cancer cells. This ability of b3 integrin to drive FGFR signaling requires the enzymatic activity of focal adhesion kinase (FAK). Importantly, covalent targeting of a conserved cysteine in the P-loop of FGFR1–4 with our newly developed small molecule, FIIN-4(, more effectively blocks 3D metastatic outgrowth as compared with currently available FGFR inhibitors. In vivo application of FIIN-4 potently inhibited the growth of metastatic, patient-derived breast cancer xenografts and murine-derived metastases growing within the pulmonary microenvironment. More... 
Mol Cancer Ther; 15(9); 2096–106. 2016 AACR.